Pathology

for Dental Students

Study questions: Musculoskeletal system pathology

Answers are here.

1.All of the following statements are true regarding rheumatoid arthritis EXCEPT:

A.Accompanied by antibodies to IgG in serum

B.Associated with formation of destructive granulation tissue (pannus)

C.Demonstrates autosomal dominant pattern of inheritance

D.Occasionally accompanied by amyloidosis

2.Feature(s) of rheumatoid arthritis include

A.Marked hypertrophy of the synovium with the formation of villi

B.Perivascular lymphocytic and plasma cell infiltration

C.Pannus

D.All of above

E.None of above

3.Sequestrum, suppurative inflammation and necrosis of bone characterize:

A.Osteosclerosis

B.Degenerative joint disease

C.Myositis ossificans

D.Osteosarcoma

E.Osteomyelitis

4. Which of the following statements is true regarding myasthenia gravis?

A.There is a reduction in acetylcholine receptors

B.Clinical manifestations depend on complications of infection

C.Diagnosis depends on identification of intracellular desmin

D.There is an autosomal dominant pattern of inheritance

E.Ptosis is diagnostic

5.Which of the following bone diseases is seen most frequently in younger patients?

A.Hyperparathyroidism

B.Osteoporosis

C.Paget's disease of bone

D.Osteosarcoma

6. All of the following occur in osteoarthritis EXCEPT:

A. Osteophytosis

B. Cysts of bone

C. Heberden's nodes

D. Pannus

E. Temporomandibular joint involvement

7.All of the following are features of degenerative joint disease EXCEPT:

A.Onset during fifth and sixth decades

B.Patients often overweight

C.Soft tissue subcutaneous nodules

D.Bony swellings (Heberden's nodes)

E.Usually affects knees, hips and spine

8.Which of the following neoplasms is the most common in bone?

A.Osteoid osteoma

B.Osteosarcoma

C.Metastatic carcinoma

D.Giant cell tumor

E.Chondrosarcoma

9.Which of the following neoplasms is the most common in bone?

A.Osteoid osteoma

B.Osteosarcoma

C.Rhabdomyosarcoma

D.Giant cell tumor

E.Chondrosarcoma

10.The arthritis seen in patients with Lyme disease:

A.Occurs in early stage

B.Is called Pott's disease

C.Commonly affects knee joints

D.Commonly affects shoulder joints

E.Precedes cardiac involvement

11.Osteoporosis

A.Decrease in bone matrix relative to mineral

B.Decrease in bone mineral relative to matrix

C.Both

D.Neither

12.Paget's disease is characterized by

A.Osteolytic phase

B.Osteogenic phase

C.Both

D.Neither

13.Osteosarcoma is associated with

A.Paget's disease

B.Loss of heterozygosity at the retinoblastoma (Rb) locus

C.Both

D.Neither

14.Multiple myeloma is accompanied by all except

A.Monoclonal immunoglobulin spike

B.Osteolytic lesions in skull

C.Increased incidence of osteosarcoma

D.Monoclonal proliferation of plasma cells

15.All of the following may be seen in patients with osteitis deformans (Paget's disease) EXCEPT:

A.Urinary hydroxyproline elevation

B.Bilateral maxilla abnormalities

C.Osteolysis circumscripta

D.X-linked pattern of inheritance

E.Polyostotic distribution

16.Which of the following statements is true regarding myasthenia gravis?

A.75 percent of patients have thymic abnormalities

B.Clinical manifestations depend on the size of infection

C.Diagnosis depends on identification of intracellular desmin

D.There is an autosomal dominant pattern of inheritance

E.The peak age of onset is 40 years

17.Desmoid refers to a tumor of aponeuroses of muscles

A.That is malignant

B.That appears malignant histologically

C.That appears benign histologically

D.That appears most frequently in men

18.Stage I Lyme disease features

A.Dermatologic and constitutional symptoms

B.Cardiac involvement

C.Arthritis

D.Neurologic involvement

19.Giant cell lesions may be present in patients with:

A.Primary hyperparathyroidism

B.Secondary hyperparathyroidism

C.Giant cell granuloma

D.All of the above

20.Microfractures, pain and pathologic fractures of long bones of older females are

            characteristic of:

A.Rickets

B.Osteomalacia

C.Osteosarcoma

D.Osteoporosis

21.Monostotic fibrous dysplasia

A.Occurs in young individuals

B.Is associated with cutaneous pigmentation

C.Is usually bilateral

D.Is a benign neoplasm

22.Which of the following causes osteitis fibrosa cystica?

A.Osteoporosis

B.Parathyroid adenoma

C.Carcinomatosis

D.Osteosarcoma

23.Hyperparathyroidism is associated with

A.Hypercementosis

B.Hypercalcemia

C.Exaggeration of osteoid seams

D.Hemangiomatosis

E.Subchondral bone cysts

24.In rheumatoid arthritis, Allison-Ghormley bodies refer to:

A.Deposits of fibrin in the synovial cavity

B.Lymphoid tissue follicles identified in the synovium

C.Proliferating synovial villi

D.Nodular skin lesions

E.Antibody-antigen immunologic complexes

25.Uricemia is characteristic of

A.Still disease

B.Acute gouty arthritis

C.Rheumatoid arthritis

D.Duchenne muscular dystrophy

E.Myasthenia gravis

26.Which type of hypersensitivity reaction occurs in rheumatoid arthritis?

A.I

B.II

C.III

D.        IV

E.V

27.Myositis ossificans can develop as result of:

A.Chromosomal translocation

B.Injury

C.Increased parathormone excretion

D.Type I collagen mutation

E.Kyphoscoliosis

28.Precocious puberty occurs in female patients with

A.Monostotic fibrous dysplasia

B.McCune-Albright syndrome

C.Paget's disease

D.Myasthenia gravis

E.Myotonic dystrophy